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butabarbital will lower the level or result of fedratinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Impact of coadministering a strong CYP3A4 inducer with fedratinib has not been examined.butabarbital will lessen the extent or result of carvedilol by influencing hepatic enzyme CYP2C9/ten metab